Keep track of Closely (one)lenacapavir will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.etravirine will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers may lead to a lessen